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Tissue Regeneration
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Intrinsic tissue regeneration in the body
Intrinsic tissue regeneration is the body’s regular maintenance cycle in which millions of tissue cells constantly undergo remodeling and restoration. It begins with circulating mesenchymal stem cells originating from bone marrow. Biochemical signals draw the stem cells to sites where growth factors have created an environment for regeneration.
Scar tissue vs regenerated tissue
Scar tissue is different from regenerated tissue. When an injury occurs, the body’s first reaction is hemostasis when fibrin and inflammatory cytokines form a blood clot or provisional scaffold. More inflammatory cells arrive, remodeling the clot into scar tissue. Collagen in scar tissue is abnormally aligned and has little elastin. Unlike regenerated tissue, scar tissue is different—and less perfect— than the surrounding tissue it replaces. Rather than triggering a scarring response, AlloDerm allows nature to follow its own regenerative process—restoring tissue to its original structural, functional, and physiological condition.
Tissue regeneration and AlloDerm
AlloDerm parallels nature. In fact, it is the ideal biological framework to harness nature’s own regenerative healing process.
During the regeneration process, the AlloDerm matrix becomes part of the existing tissue structure in four stages:
- The circulating stem cells target damaged tissue
- In the target area, these cells deposit and adhere to the matrix
- Next, the cells differentiate into tissue-specific cell types
- Finally, the differentiated cells elaborate the new matrix to
regenerate tissue
 | | Supports rapid revascularization and repopulation: The vascular architecture is endothelialized, and host stem cells migrate and bind specifically to protein components of the matrix. |
|  | | Supports remodeling to the patient’s own tissue: The matrix is now fully revascularized, repopulated and integrated into the host tissue. Proteins undergo normal breakdown and regeneration. |
|  | | Supports transition to specific host tissue: Host cells continue to respond to the local environment, and the matrix transitions into the tissue it is replacing at the site of the transplant. |
|  | AlloDerm becomes the native tissue it replaces: This histology of a clinical biopsy taken eight months post-operatively indicates that when placed in the abdominal wall next to native fascia, AlloDerm becomes rapidly revascularized and repopulated with patient fibroblast cells, then remodels and transitions into fascia-like tissue.
Source: Buinewicz B, Colony LH, Smith RJ. The Use of Human Acellular Tissue Matrix in Abdominal Wall Reconstruction - A Clinical Perspective. LifeCell Clinical Monograph Series, 2003. |
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