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Grafting
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 AlloDerm: Improving Functional Outcomes and Cosmesis in Grafting Procedures
AlloDerm - A Different Approach to Grafting
- Take a thinner autograft
- Take a thinner split-thickness graft of less than 0.008 inches instead of a full-thickness or thicker split-thickness graft
- Mesh and prepare the thinner autograft as necessary
- Perfect a new grafting technique
- Rehydrate AlloDerm in saline for tissue that’s indistinguishable from autograft, with comparable suturability cut, fold, etc
- Apply rehydrated AlloDerm to treatment area and cover with thinner autograft
- Suture or staple the composite graft as you would a traditional autograft
- Alter your approach to postprocedure care
- After graft is complete, dress according to AlloDerm protocol
- To ensure best possible AlloDerm take, take down wound dressings after 7 days instead of 3 days
- Follow normal graft care protocols to maximize functional outcomes and cosmesis
A Real Difference in Outcomes
- Less donor-site morbidity than with thicker autografts1,4-6
- Reduces scarring4,6
- Faster healing of donor site facilitates reharvesting, if necessary6
- Ideal for compromised patients (elderly and pediatric patients, as well as those with minimal donor areas)4,7
- Functional outcomes of a thick autograft, without a thick autograft
- Allows you to consistently achieve graft thickness of up to 0.020 inches
- The greater the thickness and amount of intact dermal collagen of the graft, the less wound contractures during healing8,9
- AlloDerm retains intact collagen matrix and vascular channels of human dermis to ensure take equivalent to autograft6,7
- AlloDerm has been shown to cause significantly less contractures, allowing patients more mobility, especially in hands, joints, etc5,6
A Real Difference in Cosmesis
- Better cosmesis than with a thin autograft alone
- Allows you to place up to a 0.020-inch graft in virtually every procedure
- Thicker grafts provide the best chance at approximating normal skin characteristics and may help reduce hypertrophic scarring8
- Thicker grafts are preferable if pigmentation is a concern or if the skin will undergo significant growth, as with a child8
- Ensures softer, smoother skin at treatment site after healing is complete10
- Reduces or eliminates mesh pattern that can result from grafting with autograft alone11
- Fewer hyperpigmentation or hypopigmentation problems during recovery6
- Real Human Tissue That Makes a Real Difference
- Faster healing of donor site, reduced wait for secondary grafts, and less need for postoperative reconstruction mean shorter hospital stays and faster return to work.5,6
- Allows you to place up to a 0.020-inch graft in virtually every procedure for better functional outcomes and cosmesis.6,8
- AlloDerm with a thin split-thickness autograft demonstrates take rates comparable to thicker split-thickness autograft alone.4,10
Before use, physicians should review all risk information, which can be found in the "Instructions for Use" attached to the packaging of each AlloDerm graft.
References:
- Wainwright D, Madden M, Luterman A, et al. Clinical evaluation of an acellular allograft dermal matrix in full-thickness burns. J Burn Care Rehabil. 1996;17:124-136.
- Griffey ES, Livesey SA. Production of an in vitro reconstituted skin using human neonatal foreskin keratinocytes (HFK) in combination with the dermal substrate AlloDerm®. Presented at the Congress on In Vitro Biology, May 20-24, 1995.
- Wainwright D, Nag A, Call T, Griffey S, Atkinson Y, Livesey S. Normal histological features persist in an acellular dermal transplant grafted in full-thickness burns. Poster presented at the FASEB Summer Research Conference, Repair and Regeneration: At the Interface. July 9-14, 1994.
- Achauer B, Jones L, Silverstein P. AlloDerm® acellular dermal graft facilitates burn scar reconstruction. Monograph. LifeCell Corporation. 1997.
- DeClement FA Jr, Hunt JL, Jones L, Silverstein P. The use of AlloDerm® acellular dermal graft in full-thickness burns. Monograph. LifeCell Corporation. 1997.
- Lattari V, Jones LM, Varcelotti JR, Latenser BA, Sherman HF, Barrette RR. The use of a permanent dermal allograft in full-thickness burns of the hand and foot: a report of three cases. J Burn Care Rehabil. 1997;18:147-155.
- Sheridan R, Choucair R, Donelan M, Lydon M, Petras L, Tompkins R. Acellular allodermis in burn surgery: 1-year results of a pilot trial. J Burn Care Rehabil. 1998;19:528-530.
- Rudolph R, Fisher JC, Ninnemann JL. Skin Grafting. Boston, MA; Little, Brown & Co.;1979:24,115-116.
- Brown D, Garner W, Young VL, Skin grafting: dermal components in inhibition of wound contraction. South Med J. 1990;83:789-795.
- Wainwright D. Case study: acellular allograft dermal matrix: potential as a permanent skin replacement in full-thickness burns. Case study. LifeCell Corporation. 1993.
- Wainwright DJ. Use of an acellular allograft dermal matrix (AlloDerm) in the management of full-thickness burns. Burns. 1995;21:243-248.
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